The effect of ozone injection with two different injection methods to control knee pain

Comparative effect of intra-articular Ozone injections with suprapatellar lateral and inferomedial approaches for pain control in patients with knee osteoarthritis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20131124015515N5

Enrollment

Registered

2019-03-14

Start date

2019-03-10

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoartritis. Unilateral primary osteoarthritis, unspecified knee

Interventions

Intervention 1: Intervention group: suprapatellar lateral approach? the patient is placed in a supine position, Insert the needle one centimeter high and one cm in the lateral portion of the super pe

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients older than 40 years The pain of knee osteoarthritis for more than three months Radiological findings confirming knee osteoarthritis based on the American College of Rheumatology Osteoarthritis with Grade II-III based on Kellgren-Lawrence radiology grading No effusion Signed written informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Patients with history of knee surgery Deformity and lower limb contraction Lower limb neovascular disease Acute lumbosacral pathology Injection of steroid drugs over the past two months History of inflammatory rheumatoid arthritis Infection Diabetes Pregnancy Breast feeding Body Mass Index >35 kg/m2 Patients undergoing knee surgery Knee deviation (verrucous or valgus more than 5 degrees) confirmed by three joint view Radicular pain Knee pain Anticoagulant therapy Post-traumatic arthritis History of intraArticular or ozone therapy during 12 Last month Systemic or psychiatric illness Severe osteoarthritis with Grade over III

Design outcomes

Primary

Measure	Time frame
Pain Level by visual analog scale. Timepoint: In the portal area during the first, second, third and fourth injections and knee pain before treatment, one month and three months after the last injection. Method of measurement: Visual analog scale (VAS) (0 None; 1-3 Mild; 4-7 Moderate; 8-10 Severe).;Disability Level by Oswestry Low Back Disability Questionnaire. Timepoint: Before starting treatment and three months after the last injection. Method of measurement: Oswestry Low Back Disability Questionnaire that disability is measured with 10 items. Each item is scored from 5-0, which indicates a higher score for the disability.	—

Measure

Time frame

Pain Level by visual analog scale. Timepoint: In the portal area during the first, second, third and fourth injections and knee pain before treatment, one month and three months after the last injection. Method of measurement: Visual analog scale (VAS) (0 None; 1-3 Mild; 4-7 Moderate; 8-10 Severe).;Disability Level by Oswestry Low Back Disability Questionnaire. Timepoint: Before starting treatment and three months after the last injection. Method of measurement: Oswestry Low Back Disability Questionnaire that disability is measured with 10 items. Each item is scored from 5-0, which indicates a higher score for the disability.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Masoud Hashemi MD

Shahid Beheshti University of Medical Sciences

dr.hashemi@sbmu.ac.ir+98 21 2261 2252

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026