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Comparison of the Efficacy of High-Dose Triple Therapy for Helicobacter pylori Eradication

“Comparison of the Efficacy rate of 10-Day and 14-Day High-Dose Triple Therapy with Amoxicillin, Bismuth, and Esomeprazole as First-Line Treatment for Helicobacter pylori Eradication in Patients with Dyspepsia.”

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20131124015510N7
Enrollment
200
Registered
2026-05-16
Start date
2026-02-20
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

H. pylori infection eradication. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere

Interventions

Intervention 1: Case group: The high-dose triple therapy group 10 days (Group A) received esomeprazole 40 mg (Ezonium®, Abedi Pharmacy Company), amoxicillin 1 g, and bismuth subcitrate 240 mg, each ad

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients over 18 and under 80 years of age patients who have gastric ulcer, duodenal ulcer, or erosive gastritis, patients who have no previous history of Helicobacter pylori eradication therapy positive H. pylori test confirmed by histopathology or a positive rapid urease test.

Exclusion criteria

Exclusion criteria: Patients with advanced underlying liver and kidney disease. Patients who are unwilling to participate in the study. History of previous Helicobacter pylori eradication treatment

Design outcomes

Primary

MeasureTime frame
Helicobacter pylori infection detection in patients. Timepoint: “At the time of endoscopy, gastric mucosal biopsies were obtained, and Helicobacter pylori infection was evaluated by histopathological examination.”. Method of measurement: Helicobacter pylori infection evaluation in pathology.

Secondary

MeasureTime frame
Testing and evaluation of Helicobacter pylori eradication. Timepoint: Eight weeks after completion of Helicobacter pylori eradication therapy. Method of measurement: Helicobacter pylori stool antigen test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mohammad Valizadeh Toosi

Mazandaran University of Medical Sciences

smvt514@gmail.com+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026