effect of amiodarone in reducing the incidence of atrial fibrilation

Evaluation of the prophylactic effect of amiodarone in reducing the incidence of atrial fibrilation after coronary bypass graft surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013112215490N1

Enrollment

204

Registered

2014-01-17

Start date

2014-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation. ??????????? ?????? ? ?????

Interventions

Intervention 1: Intervention 1. Amiodarone 300 mg intravenous bolus in 30-20 minutes and then 1 mg/kg in first 6 hours after surgery and 0.5 mg/kg IV infusion in next 18 hours. Intervention 2: Interve

Treatment - Drugs

Placebo

Intervention 1. Amiodarone 300 mg intravenous bolus in 30-20 minutes and then 1 mg/kg in first 6 hours after surgery and 0.5 mg/kg IV infusion in next 18 hours.

Intervention 2. Intravenous normal saline as placebo.

Eligibility

Sex/Gender

All

Age

35 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. All patients candidate for CABG 2. All patients with ASA II and III. 3. All surveyed patients are candidate for 2 or 3 grafts. Exclusion criteria: 1. Patients candidate for more than 3 grafts. 2. Incidence of any arrhythmia in placebo group. 3. Incidence of any arrhythmia other than atrial fibrillation in the amiodarone group.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Atrial fibrilation. Timepoint: within 48 hours after surgery. Method of measurement: Cardiac monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Niloofar Dadash pour

Arak University of Medical Sciences

ndadashpoor60@yahoo.com+98 34173505

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026