The effect of alpha-lipoic acid supplementation and Electrical isotonic contraction on Anthropometric parameters, body composition and Angiogenesis factor, sirtunin-1 andPGC1 a in obese people under weight loss regime

The effect of alpha-lipoic acid supplementation and Electrical isotonic contraction on Anthropometric parameters, body composition and Angiogenesis factor, sirtunin-1 and PGC1 a in obese people under weight loss regime

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20131117015424N2

Enrollment

100

Registered

2018-04-02

Start date

2018-04-03

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity. Other obesity due to excess calories

Interventions

Intervention 1: Intervention group: Individuals receive 2 capsules containing 600 mg of alpha-lipoic acid for 2 months (one hour before lunch and dinner), plus a diet with calories calculated to lose

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Body mass index is between 30-40 kg / m² Age between 18-50 Lack of systemic, inflammatory and chronic diseases (diabetes, hypertension, kidney) Lack of epilepsy Non-use of anti-inflammatory drugs, hormones, weight loss drugs and antioxidant and vitamin supplements Lack of Pregnancy and lactation Not having skin problems and allergies Not getting under a weight loss diet in the last 6 months Failure to follow a particular diet Lack of smoking and smoking

Exclusion criteria

Exclusion criteria: Systemic, inflammatory, liver, heart, kidney, and chronic diseases during the study Pregnancy Changes in diet and physical activity Unwillingness to cooperate

Design outcomes

Primary

Measure	Time frame
VEGF Angiogenesis Factor. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.;NO Concentration. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.;Sirtoin Concentration. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.;PGC1a Concentrations. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.	—

Measure

Time frame

VEGF Angiogenesis Factor. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.;NO Concentration. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.;Sirtoin Concentration. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.;PGC1a Concentrations. Timepoint: The beginning and the end of the study. Method of measurement: With ELISA method.

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Secondary

Measure	Time frame
Weight. Timepoint: The beginning and the end of the study. Method of measurement: Scales.;Waist. Timepoint: The beginning and the end of the study. Method of measurement: Meter.;Body Mass Index. Timepoint: The beginning and the end of the study. Method of measurement: Computing.;Body Slim Percentage. Timepoint: The beginning and the end of the study. Method of measurement: BIA machine.;Body Fat Percentage. Timepoint: The beginning and the end of the study. Method of measurement: BIA machine.	—

Measure

Time frame

Weight. Timepoint: The beginning and the end of the study. Method of measurement: Scales.;Waist. Timepoint: The beginning and the end of the study. Method of measurement: Meter.;Body Mass Index. Timepoint: The beginning and the end of the study. Method of measurement: Computing.;Body Slim Percentage. Timepoint: The beginning and the end of the study. Method of measurement: BIA machine.;Body Fat Percentage. Timepoint: The beginning and the end of the study. Method of measurement: BIA machine.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe zakizadeh

Ahvaz University of Medical Sciences

e.zakizade.2010@gmail.com+98 61 3333 9092

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 18, 2026