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Evaluation of preemptive effects of intravenous acetaminophe in viteroretinal surgery

Evaluation of administration effects of intravenous acetaminophen on postoperative pain, nausea and sedation score in vitroretinal surgery with generall anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201311139213N3
Enrollment
83
Registered
2014-05-12
Start date
2013-11-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitreoretinal surgery. Other retinal disorders

Interventions

Intervention 1: Control group (41 patients) received 100 milliliter of normal saline as placebo on 20 minutes before surgery and 20 minutes prior to the end of the surgery. Intervention 2: Preemptive
Placebo
Treatment - Drugs
Control group (41 patients) received 100 milliliter of normal saline as placebo on 20 minutes before surgery and 20 minutes prior to the end of the surgery.
Preemptive group (21 patients) received 15 milligram/ kilogram of acetaminophen in 100 milliliter normal saline 20 minutes before surgery and 100 milliliter normal saline 20 minutes before the opera
Preventive group (21 patients) received 100 milliliter normal saline intravenously 20 minutes before surgery and 15 milligram/ kilogram acetaminophen in 100 milliliter normal saline 20 minutes before

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: Age between 18 to 70 years exclusion criteria: opioid use within past 48 hours; psychological and neurologic disease; sever heart disease; sever liver disease; sever kidney disease; hematologic disease; metabolic and physical disease; history of chronic pain;

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: recovery, 2h after surgery.4h after surgery.24h after surgery. Method of measurement: Pain from 1 to 10 based on VRS score will be recorded.

Secondary

MeasureTime frame
Nausa. Timepoint: ricovery, 2h after surgery,4 hour after surgery, 24h surgery. Method of measurement: Its presence or absence is recorded.;Vomit. Timepoint: ricovery, 2h after surgery,4 hour after surgery, 24h surgery. Method of measurement: Its presence or absence is recorded.;Shivering. Timepoint: recovery. Method of measurement: Its presence or absence is recorded.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJalil Makarem, MD

Tehran University of Medical Sciences

j.makarem@yahoo.com+98 21 61190

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026