Cognitive Impairment. Other specified mental disorders due to brain damage and dysfunction and to physical disease
Conditions
Interventions
Intervention 1: Intervention group: Valerian tablet, 530mg, every twelve hours for two months. Intervention 2: Control group: Placebo tablet, every twelve hours, for two months.
Prevention
Placebo
Intervention group: Valerian tablet, 530mg, every twelve hours for two months.
Control group: Placebo tablet, every twelve hours, for two months.
Sponsors
Vice chancellor for research, Islamic Azad University, Sari Branch
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Patients aged between 30-70 years. 2. Coronary artery bypass surgery with cardiopulmonary bypass Exclusion criteria: 1. Other simultaneous cardiac surgery (e.g., Valve replacement) 2. Symptomatic cerebrovascular disease 3. Alcoholism 4. Psychiatric illness (any clinical diagnosis requiring therapy) 5. Drug abuse 6. Hepatic insufficiency (liver function tests>1.5 times the upper limit of normal) 7. Severe pulmonary insufficiency (requiring home oxygen therapy) 8. Renal failure (serum creatinine>2mg/dl) 9. Reluctance to do a cognitive test performance 10. Previous heart surgery 11. Preoperative left ventricular ejection fraction<30% 12. Sensitivity to valerian
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive Impairment. Timepoint: Before intervention-ten days after beginning of intervention-two month after beginning of the intervention. Method of measurement: Mini Mental State Examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Any reaction to valerian. Timepoint: Ten days after beginning of intervention-two month after beginning of the intervention. Method of measurement: Observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHadi Darvishi Khezri
Islamic Azad University, Sari Branch
Outcome results
None listed