mocusal inflammation around dental implants. Sepsis due to anaerobes, Sepsis due to other Gram-negative organisms
Conditions
Interventions
Intervention 1: Control: Instruction of oral hygiene and debridement of subgingival environment using ultrasonic scaler and glycine-based powder air polishing. Intervention 2: Intervention 1 : Two wee
Treatment - Drugs
Control: Instruction of oral hygiene and debridement of subgingival environment using ultrasonic scaler and glycine-based powder air polishing.
Intervention 1 : Two weeks after mechanical debridement, one mg of minocycline hydrochloride microspheres (Arestin OraPharma, Inc USA) will be located subgingivally in the affected sites around the im
Intervention 2 : Two weeks after mechanical debridement, 0.1 ml of Enamel Matrix Derivative Gel (Emdogain) 0.3 ml straumann will be located subgingivally in the affected sites around the implant with
Sponsors
Vice chancellor for research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: - Adults aged 18 years and older - Patients with peri-implant inflammation, defined as: Presence of bleeding on probing, probing depth more than 4mm, lack of soft tissue recession, radio-graphic bone loss less than 2mm. - Implant functioning for at least one year Exclusion criteria: - Taking systemic or local antibiotics in the past 3 months - Regular intake of anti-inflammatory drugs in the past 3 months - Any intervention for treatment of peri-implant inflammation in the past 3 months - Poor oral hygiene - Smoking - Long term treatment with any medication that affects soft and hard tissue conditions (such as phenytoin, cyclosporin, calcium canal blockers...) - Pregnancy and lactation - Sever periodontal disease - Uncontrolled diabetes or debilitating systemic disease - Drug and alcohol addiction - Allergy to tetracycline-class drug(s)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numbers of the porphyromonas gingivalis bacteria. Timepoint: Before intervention, 2 weeks and 3 months after intervention. Method of measurement: The number of bacteria with polymerase chain reaction (PCR). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Goharfar
Tabriz University of Medical Sciences, Faculty of Dentistry
Outcome results
None listed