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therapeutic effects of Carvidelol and Metoprolol in prevention of cardiac arrhythmia after open heart surgery

Comparing therapeutic effects of carvedilol and metoprolol in prevention of atrial fibrillation after coronary artery bypass surgery, double blinded study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013111015178N2
Enrollment
150
Registered
2014-01-03
Start date
2012-03-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation. Atrial fibrillation and flutter

Interventions

Intervention 1: A total of 150 patients 75 in each drug group, enroll in the study.Initiative dose is going to be 25 mg/BD in metoprolol group and will increase according to the patients’ hemodynamic
Prevention
A total of 150 patients 75 in each drug group, enroll in the study.Initiative dose is going to be 25 mg/BD in metoprolol group and will increase according to the patients’ hemodynamic responses.Cardi
A total of 150 patients 75 in each drug group, enroll in the study.Initiative dose is going to be 6.25 daily in carvideloll group and increase according to the patients’ hemodynamic responses.Cardiac

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
21 Years to 81 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients indicated for CABG surgery who did not have any contraindications for beta blocker use .Exclusion criteria: chronic obstructive respiratory failure; advanced AV block; previous AF; bradycardia (HR<60); hypotension (SBP<90); ejection fraction<35%; patients who were undergoing repair or replace of heart valve along with their CABG surgery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Atrial fibrillation. Timepoint: During the first 5 days after CABG. Method of measurement: Cardiac monitoring.

Secondary

MeasureTime frame
Ventricular fibrillation. Timepoint: During the first 5 days after CABG in ICU. Method of measurement: Cardiac monitoring.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRozita Jalalian

Mazandaran University of Medical Sciences

rozita_jalalian@yahoo.com+98 15 1222 4002

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026