The effect of Alpha lipoic acid supplementation on male infertility

The effect of Alpha lipoic acid supplementation on gene expression and activity of Glutathione S-Transferase and spermatogram in idiopathic asthenozoospermic males: A randomized, triple-blind, placebo-controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013111010181N3

Enrollment

Registered

2013-11-15

Start date

2013-11-16

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthenospermia. male infertility

Interventions

Intervention 1: Control group:Placebo placebo: Lactose, 12 weeks, 2 capsule(300 mg) per day. Intervention 2: Intervention group:Alfa lipoic acid 600 mg per day for12 weeks, 2 capsule per day(300mg).

Treatment - Drugs

Control group:Placebo placebo: Lactose, 12 weeks, 2 capsule(300 mg) per day

Intervention group:Alfa lipoic acid 600 mg per day for12 weeks, 2 capsule per day(300mg)

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Willing to participate in the study and filling out the informed consent form; they should be infertile (no conception after 12 months intercourse without any contraception); age 20-45 y.o; idiopathic asthenospermia according to WHO criteria; normal hormonal profile. Exclusion criteria: any infection in genitourinary (GU) tract; any anatomical abnormality in GU tract; any chronic disease during last 3 months; any surgery in GU tract; consumption of antioxidant supplements during last 3 months.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sperm motility. Timepoint: 12 weeks. Method of measurement: spermatogram.	—

Secondary

Measure	Time frame
Gene expression and activity of Glutathione S-Transferase. Timepoint: 12 weeks. Method of measurement: Real Time-PCR- Spectrophotometric.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Fatemeh Heidari

Ahvaz Jundishapur University of Medical Science

Haidari58@gmail.com+98 61 1373 8330

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 17, 2026