Idiopathic Recurrent Abortion. Miscarriage
Conditions
Interventions
Intervention 1: Case group are treated with prednisolone with this protocol: prednisolone 2 months before taking action to pregnancy
first week 20 mg daily
second week 15 mg daily
third to seventh week 10 mg daily
eighth week 5 mg daily.Then recheck NK-cell density , if there is suitable response, taking action to pregnancy will be allowed .After positive pregnancy test ,restarting prednisolone or placebo with
with this protocol: placebo 2 months before taking action to pregnancy
eighth week 5 mg daily.Then recheck NK-cell density , if there is suitable response, taking action to pregnancy will be allowed .After positive pregnancy test ,restarting placebo with this protocol:10
Treatment - Drugs
Case group are treated with prednisolone with this protocol: prednisolone 2 months before taking action to pregnancy
Control group with placebo before and during pregnancy
Sponsors
Avicenna Research Institute
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: female gender; being a case of idiopathic abortion; in flow cytometry of peripheral blood, CD56 more than 12 or CD 16/56 more than 8. Exclusion criteria: age less than 20 or more than 40 years old; having less than 2 abortions; history of abortion more than 20w of gestational age; uterine disorder; chromosomal disorder in couples; antiphospholipid syndrome; contraindication of corticosteroid; abnormal thyroid function test result.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abortion. Timepoint: 12th and 20th weeks of gestation. Method of measurement: Patients file.;Live birth. Timepoint: After Birth. Method of measurement: Patient file. | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral Natural Killer Cell. Timepoint: Before intervention, 2 months after intervention, 8th, 12th, 20th weeks of gestation. Method of measurement: Flow cytometry.;Chemical pregnancy. Timepoint: 1 week after retardation of mens. Method of measurement: Positive beta-hcg test.;Pre eclampsia. Timepoint: After 20th week of gestation. Method of measurement: Blood pressure measuring.;Drug Complications. Timepoint: After Treatment. Method of measurement: Patients files.;Gestational Diabetes. Timepoint: After 20th week of gestation. Method of measurement: FBS, GCT, GTT.;IUGR. Timepoint: After 28th week of gestation. Method of measurement: Obstetrical ultrasound scan.;Clinical Pregnancy. Timepoint: After 5-6 th week of gestation. Method of measurement: Obstetrical Ultra Sound Scan.;Ongoing Pregnancy. Timepoint: After 7th week. Method of measurement: Obstetrical Ultrasound Scan.;Gestational age at delivery. Timepoint: After 24th week of gestation. Method of measurement: Patient file.;Feotal Abnormality. Timepoint: At 20th weeks gestation. Method of measurement: Anomaly Ultrasound Scan. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Rashin Zargham
Avicenna Infertility and Recurrent Aborsion Center
Outcome results
None listed