Major depression. Severe depressive episode without psychotic symptoms
Conditions
Interventions
Intervention 1: control: capsule filled with 15mg starch will be given twice a day as placebo and 20mg of Fluoxetine will be given once a day as the primary treatment. Intervention 2: Intervention: c
Treatment - Drugs
control: capsule filled with 15mg starch will be given twice a day as placebo and 20mg of Fluoxetine will be given once a day as the primary treatment.
Intervention: capsules containing 15mg saffron will be given twice a day and 20mg Fluoxetine will be given once a day as the primary treatment.
Sponsors
Vice chancellor for research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: diagnosed major depression; no lipid lowering medicine or depression treatment in last 6 months; informed consent; age between 18-55 years. Exclusion criteria: history of suicide; presence of chronic disease such as metabolic disease and cancer; presence of ideas of suicide.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Serum lipids. Timepoint: at the beginning and at the end of study. Method of measurement: laboratory. | — |
Primary
| Measure | Time frame |
|---|---|
| Depressive status. Timepoint: at the beginning, 4th and 6th week of treatment. Method of measurement: Beck questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSina Jelodar
Shiraz university of medical science
Outcome results
None listed