The effect of Propofol and Midazolam on liver and renal tests in patients undergoing tracheal resection surgery

Comparison of the effect of total intravenous anesthesia with Propofol and Midazolam on liver and renal function after tracheal resection & anastomosis surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013110815322N1

Enrollment

Registered

2014-01-17

Start date

2011-09-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intravenous anesthetic drug side effect. Parenteral anaesthetics

Interventions

Intervention 1: Patients in the Midazolam group received continuous infusions of Midazolam 0.02- 0.04 mg/kg/hr for maintenance of anesthesia during surgery. Intervention 2: Patients in the Propofol g

Patients in the Midazolam group received continuous infusions of Midazolam 0.02- 0.04 mg/kg/hr for maintenance of anesthesia during surgery.

Patients in the Propofol group received continuous infusions of propofol 100-200 µg/kg/min for maintenance of anesthesia during surgery.

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: Exclusion criteria: liver or renal disease; DM; preoperative baseline elevated level of liver enzymes and renal tests; alcohol or substance abuse; known allergy to study drugs;ASA class 3 or higher. Inclusion criteria: normal preoperative baseline level of liver enzymes and renal tests; age ranging 16-60 years; ASA class 1 and 2.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Aspartate aminotransferase (AST). Timepoint: before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Alanine aminotransferase (ALT). Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Total Bilirubin. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Alkaline phosphatase. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;G-glutamyltransferase. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Lactate dehydrogenase. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Blood Urea Nitrogen (BUN). Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Creatinine. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.	—

Measure

Time frame

Aspartate aminotransferase (AST). Timepoint: before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Alanine aminotransferase (ALT). Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Total Bilirubin. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Alkaline phosphatase. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;G-glutamyltransferase. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Lactate dehydrogenase. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Blood Urea Nitrogen (BUN). Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.;Creatinine. Timepoint: Before induction of anesthesia, on the first, and third postoperative days. Method of measurement: Liasys AMS test.

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Secondary

Measure	Time frame
Heart rate. Timepoint: Before induction of anesthesia (base line), 30 minutes after Induction of anesthesia, 1,2,3 and 4 hours after initiation of surgery, at the end of surgery. Method of measurement: Electrocardiogram.;Mean arterial blood pressure (MAP). Timepoint: Before induction of anesthesia (base line),30 minutes after Induction of anesthesia, 1,2,3 and 4 hours after initiation of surgery, at the end of surgery. Method of measurement: sphygmomanometer.;Percent of arterial oxygen saturation (Spo2). Timepoint: Before induction of anesthesia (base line),30 minutes after Induction of anesthesia, 1,2,3 and 4 hours after initiation of surgery, at the end of surgery. Method of measurement: pulse oximetry.	—

Measure

Time frame

Heart rate. Timepoint: Before induction of anesthesia (base line), 30 minutes after Induction of anesthesia, 1,2,3 and 4 hours after initiation of surgery, at the end of surgery. Method of measurement: Electrocardiogram.;Mean arterial blood pressure (MAP). Timepoint: Before induction of anesthesia (base line),30 minutes after Induction of anesthesia, 1,2,3 and 4 hours after initiation of surgery, at the end of surgery. Method of measurement: sphygmomanometer.;Percent of arterial oxygen saturation (Spo2). Timepoint: Before induction of anesthesia (base line),30 minutes after Induction of anesthesia, 1,2,3 and 4 hours after initiation of surgery, at the end of surgery. Method of measurement: pulse oximetry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Tahereh Parsa

National Research Institute of Tuberculosis and Lung Diseases

tparsa849@yahoo.com+98 21 2610 9644

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026