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The effect of restricted normal saline on the volume of sodium bicarbonate use during liver transplantation.

The Effect of Intraoperative Restricted Normal Saline during Orthotopic Liver Transplantation on Amount of Administered Sodium Bicarbonate

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013110711662N5
Enrollment
75
Registered
2013-11-24
Start date
2013-02-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation. Surgical operation with transplant of whole organ

Interventions

In the restricted fluid group. patients received 5 ml/kg/hr crystalloid fluid during anesthesia for orthotopic liver transplantation
In the non restricted fluid group, patients received 10ml/kg/hr crystalloid fluid during anesrthesia for orthotopic liver transplantation

Sponsors

Vice-Chancellery of Research and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All adult patients with end-stage liver disease aged 16 and more,who will be underwent orthotropic deceased donor liver transplantation. Exclusion criteria:patients with hepatorenal syndrome type ?& ??; baseline serum potassium more than 6 meq/l; hepatopulmonary syndrome; portopulmonary hypertension; cardiac ejection fraction less than 60%; cirrhotic cardiomyopathy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Was sodium bicarbonate dosage that will used during surgery. Timepoint: At the end of hepatectomy phase. Method of measurement: According to usage volume (ml).

Secondary

MeasureTime frame
Heart rate. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By electrocardiogram.;Mean arterial blood pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By arterial catheter in radial artery(mmHg).;Central venous pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By internal jagular catheter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ali Sahmeddini

Shiraz University Of Medical Sciences

sahmeddini@sums.ac.ir+98 71 1647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026