Ischemic stroke. Cerebral infarction
Conditions
Interventions
Intervention 1: Interventional 1: Lithium carbonate 300mg tablet from alhavi company twice a day for 30 days+ standard treatment of ischemic stroke. Intervention 2: Intervention 2: Standard medical r
Treatment - Drugs
Interventional 1: Lithium carbonate 300mg tablet from alhavi company twice a day for 30 days+ standard treatment of ischemic stroke
Intervention 2: Standard medical regime of ischemic noncardioembolic stroke +placebo
Sponsors
Vice chancellor for research, Ahvaz Jundishapur University of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-age: 50-90. 2-Ischemic stroke including subtypes 1, 4, 5 of TOAST classification system (all types of ischemic stroke except cardioembolic types). 3-maximum time after stroke is not over than 48hours. 4-no participation in any another clinical trial Exclusion criteria: 1-Any type of intracranial or subarachnoid hemorrhage or hemorrhagic transformation in admission period 2-Any organ damage that interact with lithium prescription: acute or chronic renal failure(Creatinine more than 1.2), CHF(Ejection Fraction lesser than 40% or History of orthopnea or Paroxysmal nocturnal dyspnea), recent Myocardial Infarction(current 3 months), pulmonary edema, respiratory distress, history of any thyroid dysfunction,acute or chronic diarrhea with severe dehydration or blood urea nitrogen -serum creatinine ratio more than 20. 3-Any drug consumption that interact with lithium prescription(thiazides, Angiotensin converting enzyme(ACE) inhibitors, angiotensin receptor blockers except losartane, Calcium channel blockers, forusemide more than 80mg,NSAIDs except aspirin.4 -Pregnancy or lactation period in nonmenopausal females
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BDNF serum level. Timepoint: 5 and 30 days after lithium carbonate prescription. Method of measurement: ELISA-BOSTER company kit-pico gram per deciliter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate in intervention and control groups. Timepoint: the day 15 and 30 after lithium or placebo administration. Method of measurement: members counting. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Masoudi Moqaddam,MD
Ahvaz Jundishapur University of Medical Sciences
Outcome results
None listed