The effect of analgesia after intrathecal injection Bupivacaine +Dexmedetomidine in lower abdominal surgery

The effect of intrathecal Bupivacaine +Dexmedetomidine on analgesia for lower abdominal surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201310293305N6

Enrollment

100

Registered

2013-11-26

Start date

2013-03-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post spinal blockade analgesia. Other specified complications of surgical and medical care, not elsewhere classified

Interventions

Intervention 1: Intervention group: 12.5mg hyperbaric Bupivacaine (2.5cc) plus 5mg Dexmedetomidine(0.5cc)(group MD). Intervention 2: Control Group: 12.5mg hyperbaric Bupivacaine(2.5cc) plus 0.5cc Sa

Prevention

Intervention group: 12.5mg hyperbaric Bupivacaine (2.5cc) plus 5mg Dexmedetomidine(0.5cc)(group MD)

Control Group: 12.5mg hyperbaric Bupivacaine(2.5cc) plus 0.5cc Saline 0.9%

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: patients between 18 to 65 years old; ASA Class I, II; elective lower abdominal surgery. Exclusion Criteria: History of cardiovascular disease; dyspnea; diabetes;Renal or Hepatic disease or any systemic disease; history of using narcotics; alcohol; anti-convulsive, anti-psychotic and analgesia medications.Patients who had severe pain during surgery that needed to general anesthesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Analgesia after lower abdominal surgery. Timepoint: 2hours after spinal blockade until 24 hours. Method of measurement: Pain Score.	—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: Minutes:0, 5, 10, 15, 30, 60, 120 hours:6, 12, 18, 24. Method of measurement: Non Invasive BP.;Heart rate. Timepoint: Minutes:0, 5, 10, 15, 30, 60, 120 hours:6, 12, 18, 24. Method of measurement: Pulse Oximetery & ECG.;SPO2. Timepoint: Minutes:0, 5, 10, 15, 30, 60, 120 hours:6, 12, 18, 24. Method of measurement: Pulse Oximetery.;Shivering. Timepoint: Since the beginning of operation to 24 hours after surgery. Method of measurement: Observation & Shivering score.;Nausea & vomiting. Timepoint: Since the beginning of operation to 24 hours after surgery. Method of measurement: observation & question.	—

Measure

Time frame

Blood Pressure. Timepoint: Minutes:0, 5, 10, 15, 30, 60, 120 hours:6, 12, 18, 24. Method of measurement: Non Invasive BP.;Heart rate. Timepoint: Minutes:0, 5, 10, 15, 30, 60, 120 hours:6, 12, 18, 24. Method of measurement: Pulse Oximetery & ECG.;SPO2. Timepoint: Minutes:0, 5, 10, 15, 30, 60, 120 hours:6, 12, 18, 24. Method of measurement: Pulse Oximetery.;Shivering. Timepoint: Since the beginning of operation to 24 hours after surgery. Method of measurement: Observation & Shivering score.;Nausea & vomiting. Timepoint: Since the beginning of operation to 24 hours after surgery. Method of measurement: observation & question.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Ebrahim Alijanpour

Babol University Of Medical Sciences

dralijanpour@yahoo.com; ans_dep@yahoo.com+98 11 1223 8296

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026