Hypotension. Hypotension due to drugs
Conditions
Interventions
Intervention 1: Intervention 1. Ondansetron, 4 milligrams (2 ml), slow IV injection in 30 seconds
made in Tehran Chemistry Pharma Co. with chemical composition (RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4(9H)-one. Intervention 2: Intervention 2. Ketamine, 25 millig
made in TRITTAU company, GERMANY, with chemical composition (RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone. Intervention 3: Intervention 3. Normal saline, 2 ml, IV injection in control group.
Prevention
Placebo
Intervention 1. Ondansetron, 4 milligrams (2 ml), slow IV injection in 30 seconds
made in Tehran Chemistry Pharma Co. with chemical composition (RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4(9H)-one
Intervention 2. Ketamine, 25 milligrams (volume 2 ml with distilled water), IV injection
made in TRITTAU company, GERMANY, with chemical composition (RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
Sponsors
Arak University of Medical Sciences, Vice Chancellor for Research
Eligibility
Sex/Gender
Female
Age
15 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Pregnant women candidate for elective cesarean with spinal anesthesia who referred to Taleghani hospital, Arak. Exclusion criteria: Dissatisfaction of patient; Hypertension; Cardiovascular diseases; Body mass index upper 35; History of liver disease; History of migraine and seizure; Allergy to ondansetron; History of taking any medications that affect blood pressure or heart rate; Failure of spinal anesthesia; In top spinal cord Injuries; Need to additional drugs
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure. Timepoint: Before spinal anesthesia and every five minutes to thirty minutes after taking drug. Method of measurement: Sphygmomanometer.;Diastolic blood pressure. Timepoint: Before spinal anesthesia and every five minutes to thirty minutes after taking drug. Method of measurement: Sphygmomanometer.;Arterial O2 saturation. Timepoint: Before spinal anesthesia and every five minutes to thirty minutes after taking drug. Method of measurement: Pulse oximeter.;Heart rate. Timepoint: Before spinal anesthesia and every five minutes to thirty minutes after taking drug. Method of measurement: Cardiac monitor.;Level of consciousness. Timepoint: Before spinal anesthesia and thirty minutes after taking drug. Method of measurement: Ramsay score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Saeid Bagherbandi
Arak University of Medical Sciences
Outcome results
None listed