Gestational diabet. Diabetes mellitus in pregnancy, unspecified
Conditions
Interventions
Intervention 1: In the glibenclamide group, patients will take 1.25 mg oral tablet glibenclamid, once daily and If need, it will increase three days to reach the maximum daily 20 mg.If glibenclamide r
Treatment - Drugs
In the glibenclamide group, patients will take 1.25 mg oral tablet glibenclamid, once daily and If need, it will increase three days to reach the maximum daily 20 mg.If glibenclamide reach to maximum
In insulin group, treated will be start with 0.2 U/kg insulin twice daily injections subcutaneously. If needed, it will increase every 3 days to achieve normal levels of blood sugar. The patient's blo
Sponsors
Vice Chancellor for Research, Kashan University of Medical Sciences and Health Service
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: female age between 18 to 45 years; singleton pregnancy; no history of diabetes before pregnancy; gestational age between 11-33 weeks Exclusion criteria: premature rupture of membrane; severe infectious diseases; cardiovascular diseases; acute respiratory failure; hematological disease; renal disease; liver disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Birth Mother Trauma. Timepoint: Immediately after delivery. Method of measurement: Observation.;Fetal anomaly. Timepoint: Immediately after delivery. Method of measurement: Observation.;APGAR score. Timepoint: APGAR score 1and 5 minute after birth. Method of measurement: Observation and examination.;Birthweight and birthweight percentiles. Timepoint: Immediately after delivery. Method of measurement: Scales and calculate percentile.;Blood Sugar. Timepoint: From one half hour up to 3 hours. Method of measurement: Blood test.;Blood calcium. Timepoint: One week after birth. Method of measurement: Blood test.;Neonatal icterus. Timepoint: One week after birth. Method of measurement: Blood sugar.;Shoulder dystocia. Timepoint: In the delivery room. Method of measurement: Observation.;Perinatal death. Timepoint: ?From the second half of gestation to 28 days after birth. Method of measurement: Follow the samples and study their documents.;Respiratory distress. Timepoint: Immediately to 4 hours after birth. Method of measurement: Observation and examination of newborn.;Method of delivery. Timepoint: Date of Birth. Method of measurement: Observation.;Birth Mother Trauma. Timepoint: During and after childbirth. Method of measurement: Observation.;Maternal hypoglycemia. Timepoint: Once every three days until it becomes normal and then 4 times a day every week until delivery. Method of measurement: Blood glucose testing in the Shabih Khani hospital laboratory.;Preeclapsia. Timepoint: ?From the second half of pregnancy up to 24 hours after birth. Method of measurement: Blood pressure measurement, urinalysis, and clinical symptoms examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Need to be admitted to the neonatal intensive care unit. Timepoint: From birth until one week after delivery. Method of measurement: Follow up with the call and physical exam in infants hospitalized. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Tayebe Ghasemi
Kashan University of Medical Sciences, Faculty of Medicine
Outcome results
None listed