Closure of patent ductus arteriosus. patent dactus arterioussus
Conditions
Interventions
Intervention 1: Case Groups: mg/kg20 oral ibuprofen as an initial dose every 24 hours for two days will receive mg/kg10. Intervention 2: Control group: mg/kg10 oral ibuprofen as an initial dose every
Treatment - Drugs
Case Groups: mg/kg20 oral ibuprofen as an initial dose every 24 hours for two days will receive mg/kg10.
Control group: mg/kg10 oral ibuprofen as an initial dose every 24 hours for two days and mg/kg5 will receive.
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 3 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:term infants (gestational age 37-42 weeks); Life Age = 3 days of patent ductus arteriosus by echocardiography ; Proof of completion of an informed consent form Exclusion criteria: There is a reluctance to participate in the study ; Contraindications including ibuprofen creatinine> 8/1; platelet count less than 50,000 ;active gastrointestinal hemorrhage or intraventricular hemorrhage (confirmed by ultrasound); Antrkvlyt necrosis and sepsis; patent ductus arteriosus associated with other disorders; such as TORCH (intrauterine infection).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal bleeding. Timepoint: Before treatment - after each drug administration. Method of measurement: Blood.;Platelet count. Timepoint: Before treatment - after each drug administration. Method of measurement: Blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: Before treatment - after each drug administration. Method of measurement: blood. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Parstoo Molaei Tavana
Arak University of Medical Sciences
Outcome results
None listed