Down syndrome. Down syndrome
Conditions
Interventions
Intervention 1: In group 1 a capsule contained 400 IU alpha tocopherol will give to the children every day after dinner or lunch meal for 4 months. Intervention 2: In group 2 a capsule contained 100
Treatment - Other
Treatment - Drugs
In group 1 a capsule contained 400 IU alpha tocopherol will give to the children every day after dinner or lunch meal for 4 months.
In group 2 a capsule contained 100 mg alpha lipoic acidl will give to the children every day after dinner or lunch meal for 4 months.
In group 3 a capsule contained only vegetable oil as a placebotocopherol will give to the children every day after dinner or lunch meal for 4 months.
Sponsors
Exceptional Children Institute
Eligibility
Sex/Gender
All
Age
7 Years to 15 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:confirmation of regular trisomy 21 in children by cytogenetic analysis; not on any medication or vitamin supplementation therapy for six months before the start of intervention.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDA. Timepoint: before intervention and after 4 months. Method of measurement: The determination of MDA levels will performed by method of Satho . In this method the reaction of MDA with Thiobarbituric acid (TBA) creates a complex which is determined spectrophotometrically.;Urinary 8-hydroxydeoxyguanosine (8OHdG). Timepoint: before intervention and after 4 months. Method of measurement: 8OHdG in urine samples will assessed using an enzyme-linked immunosorbent assay (ELISA) kit (8OHdG Quantitation, Cell Biolabs, Inc. San Diego ). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Seyyed Mostafa Nachvak
Exceptiona Children Research
Outcome results
None listed