The effect of gemifloxacin in treatment of H.pylori infection

Comparision of two quadriple regimen amoxicillin, bismuth subsalicylate, pantoprazole, clarythromycin and amoxicillin, bismuth subsalicylate, pantoprazole, gemifloxacin in eradication of H.pylori infection

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201310221155N17

Enrollment

182

Registered

2014-09-03

Start date

2013-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyspepsia. Dyspepsia

Interventions

Intervention 1: Control group take cap amoxicillin 500 miligram two numbers every 12 hours, tab bismuth subsalicylate 120 miligram two numbers every 12 hours, tab pantoprazole 20 miligram one number d

Treatment - Drugs

Control group take cap amoxicillin 500 miligram two numbers every 12 hours, tab bismuth subsalicylate 120 miligram two numbers every 12 hours, tab pantoprazole 20 miligram one number daily, tab claryt

Intervention group take cap amoxicillin 500 miligram two numbers every 12 hours, tab bismuth subsalicylate 120 miligram two numbers every 12 hours, tab pantoprazole 20 miligram one number daily, tab g

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: New cases of H.pylori infection; patients between 18 to 80 years old Exclusion criteria: The pregnant and brest feeding women; gastric and esophagial malignancies; pylor stenosis; iiver cirrhosis; opium addicts; hypersensitivity to amoxicillin; bismuth subsalicylate; pantoprazole; clarythromycin; gemifloxacin; using cholestyramine; renal failure; history of sizzure; favism and hematologic disorders; incomplete treatment (under 80%); consent to continue treatment; history of H.pylori treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Helicobacter pylori eradication. Timepoint: 12 weeks. Method of measurement: Ureas Breath Test with C14.	—

Secondary

Measure	Time frame
Comparision of two quadriple regimen amoxicillin, bismuth subsalicylate, pantoprazole, clarythromycin and amoxicillin, bismuth subsalicylate, pantoprazole, gemifloxacin in eradication of H.pylori infection. Timepoint: 8-12 weeks. Method of measurement: UBT.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarahnaz Joukar

Gastrointestinal and Liver Diseases Research Center

info@gldrc.org+98 13 1553 5116

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026