The effect of restricted fluid therapy on posoperative renal and pulmonary complications following liver transplantation.

Restricted Crystalloid fluid Therapy during Liver Transplant Surgery and Its Effect on Pulmonary and Renal insufficiency in the Early postoperative period. A randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013101811662N4

Enrollment

Registered

2013-11-11

Start date

2013-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation. Surgical operation with transplant of whole organ

Interventions

Intervention 1: In the restricted fluid group. patients received 5 ml/kg/hr crystalloid fluid during anesthesia for orthotopic liver transplantation. Intervention 2: In the non restricted fluid group,

Treatment - Other

In the restricted fluid group. patients received 5 ml/kg/hr crystalloid fluid during anesthesia for orthotopic liver transplantation.

In the non restricted fluid group, patients received 10ml/kg/hr crystalloid fluid during anesrthesia for orthotopic liver transplantation

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Eligible participants are all adult patients with end-stage liver who will candidate for liver transplantation. Exclusion criteria: The patients with history of Asthma; chronic obstructive lung disease; hepatopulmonary syndrome; hepatopulmonary hypertension; hepatorenal syndrome; renal failure.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Incidece of acute renal failure. Timepoint: 1st day postoperation, 2nd day post operation, 3rd day postoperation. Method of measurement: Acute renal failure is define according to serum creatinine.;Incidence of acute respiratory failure. Timepoint: 1st day postoperation, 2nd day post operation, 3rd day postoperation. Method of measurement: By doiing arterial blood gas.	—

Secondary

Measure	Time frame
Heart rate. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By electrocardiogram.;Mean arterial blood pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By arterial catheter in radial artery(mmHg).;Cardiac output. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By NICO system for measuring noninvasive CO.;Central venous pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By internal jagular catheter.	—

Measure

Time frame

Heart rate. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By electrocardiogram.;Mean arterial blood pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By arterial catheter in radial artery(mmHg).;Cardiac output. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By NICO system for measuring noninvasive CO.;Central venous pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By internal jagular catheter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ali Sahmeddini

Shiraz University Of Medical Sciences

sahmeddini@sums.ac.ir+98 71 1647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026