Evaluation of freezing - thawing method in reducing the CMV(Cytomegalovirus) Viral load in the breast milk of mothers with preterm infants

Evaluation of freeze-thawing method in reducing viral load of Cytomegalovirus in the breast milk of preterm infants.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201310164113N6

Enrollment

Registered

2015-10-05

Start date

2015-06-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cytomegalovirus. Cytomegaloviral disease, unspecified

Interventions

Intervention 1: Control group: We couldn't choose a control group because of ethical limitations of finding CMV virus in the breast milk of the mothers with preterm infants and not doing any intervent

Prevention

Control group: We couldn't choose a control group because of ethical limitations of finding CMV virus in the breast milk of the mothers with preterm infants and not doing any interventions such as fre

Intervention group: Freezing the breast milk at -20°C for 72 hours and then thawing it in refrigerator

Eligibility

Sex/Gender

All

Age

1 Days to 3 Months

Inclusion criteria

Inclusion criteria: Inclusion criteria: mothers with preterm infants (under 32 weeks) or low birth weight (below 2000 grams); Mothers who are immune to CMV (IgG+,IgM-); Mothers with acute CMV infection, based on serologic findings (IgG+,IgM+) Exclusion criteria: mothers with infants more than 2000 grams or more than 32 weeks of gestation; Seronegative mothers (IgG-,IgM-)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The Cytomegalovirus l load in milk. Timepoint: Before and after 72 hours of freezing in -20 degree of Celcius. Method of measurement: Using real time PCR(copies/mL).	—

Secondary

Measure	Time frame
Cytomegalovirus load in infant blood. Timepoint: 2 -3 months of age in infants. Method of measurement: Assessing infants' urine samples with real time PCR.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Bagher Hosseini MD

Pediatric Health Research Center, Tabriz University of Medical Sciences

hossainm@tbzmed.ac.ir+98 41 3526 2265

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026