Effect of low copper diet and penicillamine combination on high grade brain glioma

Effect of low copper diet and penicillamine combination on VEGF, IL-6, IL-8, TNFa and Karnovski performance score in high grade brain glioma after Gamma Knife Radiosurgery in Iran Gamma Knife Center

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013101415018N1

Enrollment

Registered

2013-10-27

Start date

2013-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain tumor. Glioblastoma multiforme unspecified site

Interventions

Intervention 1: Dietary and drug intervention for intervention group. Penicillamine capsule 250 mg every 6 hours, orally for 3 months. Low-copper diet according to table provided to patients for 3 m

Treatment - Drugs

Dietary and drug intervention for intervention group. Penicillamine capsule 250 mg every 6 hours, orally for 3 months. Low-copper diet according to table provided to patients for 3 months.

The control group received a placebo capsule of 250 mg orally every 6 hours for 3 months

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: pathologic diagnosis; tumor recurrence; Age equal to or more than 18 years ;KPS equal to or more than 60 (the status of neurological function); informed consent;literacy Exclusion criteria: Avastin (Bevacizumab)use; reduction serum copper to less than 70 micrograms per deciliter;allergy to penicillin and penicillamine; pregnancy; Lack of adequate hematologic, hepatic and renal function

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Vascular endothelial growth factor. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Interleukin-6. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Interleukin-8. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Tumor Necrosing Factor. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Karnovski Performance Score(KPS). Timepoint: Before intervention,one and a half months after the intervention and at the end of intervention. Method of measurement: How to measure: clinical, scale:table.	—

Measure

Time frame

Vascular endothelial growth factor. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Interleukin-6. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Interleukin-8. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Tumor Necrosing Factor. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Karnovski Performance Score(KPS). Timepoint: Before intervention,one and a half months after the intervention and at the end of intervention. Method of measurement: How to measure: clinical, scale:table.

—

Secondary

Measure	Time frame
Drug complications. Timepoint: During the intervention. Method of measurement: Patient quote and physical exam.;Serum copper. Timepoint: Before intervention,one and a half months after the intervention and at the end of intervention. Method of measurement: How to measure: biochemical, scale: micro gram per deciliter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Feli

Tehran University of Medical Sciences,School of Nutritional Sciences and Dietetics

dr_feli@yahoo.com+98 21 8670 4759

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026