The Effect of Ketogenic Diet in the Treatment of Drug-Resistant Epilepsy

The effect of ketogenic diet on the serum levels of ketone bodies and arachidonic acid and their association with oxidative stress indices in children with drug-resistant epilepsy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20131012014988N4

Enrollment

Registered

2018-05-15

Start date

2018-04-21

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug-resistant epilepsy. Epilepsy and recurrent seizures

Interventions

Intervention group: The patients under the supervision of a physician will undergo a six-month course of ketogenic diet, which includes a ratio of 4 to 1 or 3 to 1 (in children of low age) from fat to

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Inclusion criteria

Inclusion criteria: Children under the age of 18 with epilepsy Patients referring to the neurology department of Tabriz Children Hospital.

Exclusion criteria

Exclusion criteria: Having pathological underlying diseases affecting the metabolism of drugs such as liver impairment, renal failure, blood diseases, and malignancies.

Design outcomes

Primary

Measure	Time frame
The serum level of beta-hydroxybutyrate that is the index of the ketone bodies. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Spectrophotometry.;Serum level of arachidonic acid that is an unsaturated fatty acid. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Enzyme linked-immunosorbent assay (ELISA).;The serum levels of malondialdehyde (MDA) that is an oxidative stress marker of the lipids. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Spectrophotometry.;The serum levels of 8-Hydroxydeoxyguanosine (8-OHdG) that is an oxidative stress marker of DNA. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Enzyme linked-immunosorbent assay (ELISA).	—

Measure

Time frame

The serum level of beta-hydroxybutyrate that is the index of the ketone bodies. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Spectrophotometry.;Serum level of arachidonic acid that is an unsaturated fatty acid. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Enzyme linked-immunosorbent assay (ELISA).;The serum levels of malondialdehyde (MDA) that is an oxidative stress marker of the lipids. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Spectrophotometry.;The serum levels of 8-Hydroxydeoxyguanosine (8-OHdG) that is an oxidative stress marker of DNA. Timepoint: At the beginning of the study (before the intervention), three, and six months after the onset of the ketogenic diet. Method of measurement: Enzyme linked-immunosorbent assay (ELISA).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Moahhamad Barzegar

Tabriz University of Medical Sciences

phrc_mb@tbzmed.ac.ir+98 41 3526 2265

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026