The effect of tranxamic acid and diclofenac suppository on reducing postoperative pain and bleeding in patients undergoing spinal anesthesia for cesarean

Comparison of efficacy of combination diclofenac suppository and tranxamic acid with diclofenac suppository and tranxamic acid alone on pain and bleeding in patients undergoing spinal anesthesia for cesarean tostoperative bleeding in patients undergoing spinal anesthesia for cesarean

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013100914961N1

Enrollment

210

Registered

2013-11-21

Start date

2011-04-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal anesthesia. Complications of anaesthesia during labour and delivery

Interventions

Intervention 1: The first group tranxamic acid 10 cc per kilogram of body weight intravenously for 5 to 10 minutes before the start of the section,. Intervention 2: The second group of diclofenac supp

Treatment - Drugs

The first group tranxamic acid 10 cc per kilogram of body weight intravenously for 5 to 10 minutes before the start of the section,

The second group of diclofenac suppositories 100 mg, 5 to 10 minutes before the start of the section

The third group combination of tranxamic acid 10 cc per kilogram of body weight intravenously and diclofenac suppositories 100 mg for 5 to 10 minutes before the start of section

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: pregnant women aged 18 to 40 years ; selection for cesarean section; full satisfaction of the spinal anesthesia;have no underlying disease; don’t have any prohibition for spinal anesthesia and allergy to anesthetics and the other drugs;not using Hypnotics and anti-anxiety drugs Exclusion criteria: presence of underlying disease;prohibition to spinal anesthesia and allergy to anesthetics and the other drugs; using hypnotics and anti-anxiety drugs; patients with hemoglobin less than 10;patients with detached placenta, placenta Acreta, placenta previa;multiple;history of thromboembolic disease ;any coagulopathy; patients with a BMI over 35 ; kidney trouble;polyhydroamnious and oligo hydroamnious

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The amount of bleeding during sesarian. Timepoint: during laber and 24 hours after laber. Method of measurement: according check list (calculating gas and longas during sesarian and HB 24 hours after sesarian).;The amount of pain after cesarian. Timepoint: during laber and 24 hours after laber. Method of measurement: according to the visual pain scale.	—

Secondary

Measure	Time frame
The level of the pain after surgery. Timepoint: 24 hours afte surgery. Method of measurement: according of VPS.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Fatemeh Farajisoleymani

The school of Medicine of Qazvin

fnarjisoleymani@qums.ac.ir+98 28 1333 5800

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026