The effect of supplementation with organic selenium-vitamin E on male infertility

The effect of supplementation with organic selenium-vitamin E on sperm parameters, serum levels of androgen, sexual function, and quality of sexual life in men with idiopathic infertily: A triple blind randomized controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20131009014957N20

Enrollment

120

Registered

2025-08-25

Start date

2025-09-21

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Male infertility

Interventions

Intervention 1: Intervention group: Selenium and vitamin E supplement receiving group. Intervention 2: Intervention group: Only vitamin E receiving group. Intervention 3: Control group: Placebo.

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: The normal fertility of the spouse Infertile married men for at least one year with idiopathic oligoasthenozoospermia in terms of sperm count, motility, or sperm morphology based on the standards of the World Health Organization Absence of alcohol and drug addiction Willingness to participate in the study

Exclusion criteria

Exclusion criteria: Azoospermia Getting infections and anatomical abnormalities of the genital system Suffering from varicocele Performing hip surgery or needing to do it Suffering from chronic diseases History of receiving chemotherapy drugs Taking any other chemical or herbal medicine for infertility Abnormal karyotype

Design outcomes

Primary

Measure	Time frame
Semen parameters. Timepoint: Three months after the intervention. Method of measurement: Laboratory sample.;Serum levels of androgen. Timepoint: Three months after the intervention. Method of measurement: Laboratory sample.;Average sexual performance score. Timepoint: At the beginning of the study and three months after the intervention. Method of measurement: Using Brief Sexual Function Inventory (BSFI) consisting 11 questions.;The average score of the quality of sexual life. Timepoint: At the beginning of the study and three months after the intervention. Method of measurement: Using the Sexual Quality of Life-M (SQOL-M), which consists of 11 questions.	—

Measure

Time frame

Semen parameters. Timepoint: Three months after the intervention. Method of measurement: Laboratory sample.;Serum levels of androgen. Timepoint: Three months after the intervention. Method of measurement: Laboratory sample.;Average sexual performance score. Timepoint: At the beginning of the study and three months after the intervention. Method of measurement: Using Brief Sexual Function Inventory (BSFI) consisting 11 questions.;The average score of the quality of sexual life. Timepoint: At the beginning of the study and three months after the intervention. Method of measurement: Using the Sexual Quality of Life-M (SQOL-M), which consists of 11 questions.

—

Secondary

Measure	Time frame
Serum biomarkers of oxidative stress. Timepoint: Three months after the intervention. Method of measurement: Laboratory sample.;Pregnancy rate. Timepoint: Three months after the intervention. Method of measurement: Laboratory sample.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contact?Azizeh Farshbaf-Khalili

Tabriz University of Medical Sciences

farshbafa@tbzmed.ac.ir+98 41 3335 2073

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026