Polycystic Ovarian Syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention group: Receiving 28 soft capsules of clove oil (containing Eugenol) one daily after lunch, along with 21 placebo LD tablets containing an ineffective substance (exactly th
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: The diagnosis of PCOS according to the Rotterdam criteria Age 18 to 45 years Being literate BMI between 18.5 and 30 Not using hormonal contraceptives or any other type of hormonal medication currently and during the last three months
Exclusion criteria
Exclusion criteria: Relative and absolute contraindications of LD pills (having blood pressure above 140/90, smoking and alcohol consumption, pregnancy or breastfeeding, alcohol consumption, smoking, suspicion of breast cancer, coronary heart disease, endometrial carcinoma, etc.) Women suffering from amenorrhea Women undergoing infertility treatment at the time of study Previous surgery on one or both ovaries Allergy to clove oil Disorders that cause hyperandrogenism (having Cushing's syndrome, adrenal hyperplasia, androgen-producing tumors, etc.) Thyroid disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The serum levels of dehidroepyandrosteron(DHEA) and total testosterone. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: By the ELISA method using the relevant kits.;Hirsutism score. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: Using the Ferriman–Gallwey scoring system. | — |
Secondary
| Measure | Time frame |
|---|---|
| The normalization of menstrual cycles. Timepoint: At the beginning of the study and in each 28-day cycle for 3 cycles during the intervention. Method of measurement: Using the menstrual disorders questionnaire.;The serum levels of fasting Blood glucose and insulin. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: By spectrophotometry and ELISA method.;The serum levels of gonadotropins (FSH and LH). Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: By ELISA method using the relevant kits.;Anthropometric indices (waist circumference, hip circumference, body bass index). Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: Using anthropometric tools.;Quality of life score. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: Using the health-related quality of life questionnaire of women with polycystic syndrome made by Cronin et al. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzizeh Farshbaf-Khalili
Tabriz University of Medical Sciences
Outcome results
None listed