stress related mucosal disease. erosion (acute) of stomach
Conditions
Interventions
Intervention 1: Patients were randomized to treat in 3 groups. Group 1 took omeprazole oral suspension (40 mg every day) via a nasogastric tube. Intervention 2: Group 2 treated with pantoprazole oral
Treatment - Drugs
Patients were randomized to treat in 3 groups. Group 1 took omeprazole oral suspension (40 mg every day) via a nasogastric tube.
Group 2 treated with pantoprazole oral suspension (40 mg every day) via a nasogastric tube.
Paients in the control group took interavenous pantoprazole. (40 mg every day)
Sponsors
Masih Daneshvari National Research Institute of Tuberculosis and Lung Diseases
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients of =16 yrs of age; anticipated stay of =72 hrs in ICU; required mechanical ventilation more than 48 hrs; APACHE II score =11; have a nasogastric or orogastric tube in place; have at least one additional risk factor for upper GI bleeding Exclusion criteria: status of no CPR; delay of >48 hrs from time of initial eligibility; history of gastric surgery; allergy to omeprazole or pantoprazole; active GI bleeding; significant risk of swallowing blood; admission for upper GI surgery; known upper GI lesions that might bleed; inability to take a suspension by nasogasrtic tube; end- stage liver disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean gastric pH on each trial day. Timepoint: before and 1-2.5 hrs after drug adminstration. Method of measurement: pH meter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Active upper GI bleeding. Timepoint: every day up to 14 days. Method of measurement: gastroccult test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactYasamin Dabiri
Shahid Beheshti University of Medical Sceineces, Faculty of pharmacy
Outcome results
None listed