Type 2 diabetes. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group will receive daily 3 tablets of silymarin with meal for 45 days (each tablets of silymarin contains 140 milligrams pure silymarin). silymarin tablets will be purchas
Goldaru Herbal Products Pharmaceutical Company. All the patients will receive the tablets on every two weeks base and will be monitored for consumption continuation and any possible adverse effects by
Treatment - Drugs
Placebo
Intervention group will receive daily 3 tablets of silymarin with meal for 45 days (each tablets of silymarin contains 140 milligrams pure silymarin). silymarin tablets will be purchased from the Live
The control group will receive daily 3 tablets of placebo with meal for 45 days. (Placebo tablets will be produced at the faculty of pharmacy of Tabriz University of medical sciences).
Sponsors
Vice chancellor for Research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Type 2 diabetes for at least 6 months; age between 20-50 (both of gender) years and usage of blood glucose lowering drugs. Exclusion criteria: usage of nutritional supplements in the past 3 months or during the study; usage of insulin; Pregnancy or lactation; BMI more than 35 and lower than 27; Renal and liver failure; Cardiovascular disease; Thyroid disorders; History of allergy; Smoking; Alcohol usage; Following a specific diet; Taking corticosteroids or Immunosuppressive drugs,…
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood glucose. Timepoint: Baseline and after 45 days of intervention. Method of measurement: Enzymatic colorimetric.;Insulin resistance. Timepoint: Baseline and after 45 days of intervention. Method of measurement: HOMA-IR calculation.;Fasting insulin serum. Timepoint: Baseline and after 45 days of intervention. Method of measurement: ELISA assay.;Lipid profiles (TC, TG, LDL-C, HDL-C). Timepoint: Baseline and after 45 days of intervention. Method of measurement: Enzymatic methods for TC,TG and HDL-C For LDL-C : Freidwald’s formula: LDL-C = TC- HDL-C - (TG/5).;Hs-CRP. Timepoint: Baseline and after 45 days of intervention. Method of measurement: immunoturbidimetry.;Serum malondialdehyde (MDA). Timepoint: Baseline and after 45 days of intervention. Method of measurement: spectrophotometry.;Serum total antioxidant capacity. Timepoint: Baseline and after 45 days of intervention. Method of measurement: spectrophotometry.;GPX activity. Timepoint: Baseline and after 45 days of intervention. Method of measurement: spectrophotometry.;SOD activity. Timepoint: Baseline and after 45 days of intervention. Method of measurement: spectrophotometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Calorie and nutrients intake. Timepoint: before and after 45 dyas intervention. Method of measurement: 24-h recall Questionnaire.;Anthropometric index(weight, height,WHR and Body Mass. Timepoint: before and after 45 days intervention. Method of measurement: Analogue scale for weight and weight(Kg)/Square Height for body mass index.;Systolic and diastolic blood pressure. Timepoint: before and after 45 days intervention. Method of measurement: standard barometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSoraiya Ebrahimpour Koujan
Tabriz University of Medical Sciences
Outcome results
None listed