Effect of ketamin- nesdonal combination in induction of aneasthesia in CABG patiant with low ejection fraction

Comparison of the Hemodynamic Changes of two regimens thiopental Na - ketamin & etomidate during anesthesia induction in low EF CABG patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201309242883N4

Enrollment

100

Registered

2014-01-08

Start date

2011-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerotic cardiovascular disease. Atherosclerotic cardiovascular disease

Interventions

Intervention 1: Control group: Induction of aneasthesia with etomidate 0.2 mg/kg. Intervention 2: Intervention group: Induction of aneasthesia with nesdonal 3mg/kg+ ketamin 1mg/kg.

Treatment - Other

Control group: Induction of aneasthesia with etomidate 0.2 mg/kg

Intervention group: Induction of aneasthesia with nesdonal 3mg/kg+ ketamin 1mg/kg

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:1- Elective surgery 2-Age range 40 to 70 3-EF low than 50% Exclusion criteria:1- Adrenal insuficiency 2-Intake of etomidate or nesdonal in one week 3-Corton intake in six mounth 4-sensitivity to etomidate or nesdonal 5-sepsis, endocaditis, chronic inflamatory disaeses 6-sever norologic or psychiatric diseases 7-any other operation with CABG 8-CABG with great vessel operation (et.bental) 9-dificult intubation(laryngoscopy more than 30 secend)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: before aneasthesia, one minute after injection of hypnotic, one minute before,1,2&3 minute after laryngoscopy. Method of measurement: Invasive bloob pressure monitor.;Diastolic blood pressure. Timepoint: before aneasthesia, one minute after injection of hypnotic, one minute before,1,2&3 minute after laryngoscopy. Method of measurement: Invasive bloob pressure monitor.;Mean arterial blood pressure. Timepoint: before aneasthesia, one minute after injection of hypnotic, one minute before,1,2&3 minute after laryngoscopy. Method of measurement: Invasive bloob pressure monitor.	—

Measure

Time frame

Systolic blood pressure. Timepoint: before aneasthesia, one minute after injection of hypnotic, one minute before,1,2&3 minute after laryngoscopy. Method of measurement: Invasive bloob pressure monitor.;Diastolic blood pressure. Timepoint: before aneasthesia, one minute after injection of hypnotic, one minute before,1,2&3 minute after laryngoscopy. Method of measurement: Invasive bloob pressure monitor.;Mean arterial blood pressure. Timepoint: before aneasthesia, one minute after injection of hypnotic, one minute before,1,2&3 minute after laryngoscopy. Method of measurement: Invasive bloob pressure monitor.

—

Secondary

Measure	Time frame
Heart rate per minute. Timepoint: before aneasthesia, one minute after injection of hypnotic, one minute before,1,2&3 minute after laryngoscopy. Method of measurement: manitor.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadreza Habibi

Mazandaran University of Medical Sciences

mohammadreza.habibi@gmail.com+98 15 1222 3023

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026