Melasma. Chloasma
Conditions
Interventions
Intervention 1: Intervention group : Tranexamic acid , 250 mg capsules , 3 times a day with hydroquinone 4% cream every night for 3 months. Intervention 2: Control group : Hydroquinone 4% cream ev
Treatment - Drugs
Intervention group : Tranexamic acid , 250 mg capsules , 3 times a day with hydroquinone 4% cream every night for 3 months.
Control group : Hydroquinone 4% cream every night for 3 months .
Sponsors
Vice Chancellor for Reasearch of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria : Age between 18 - 65 years old ; Symmetric distribution of melasma ; Informed consent. Exclusion criteria : Usage of hydroquinone ,topical or oral retinoids ,topical corticosteroid ,alfa hydroxyl acids or other drugs effective to skin pigmentation 3 months prior to the study ; Usage of peeling agents 3 months prior to the study ; Laser therapy 3 months prior to the study ; Sunburn , high exposure to sunlight or solarium usage 3 months prior to the study ; Usage of oral contraceptive concurrently ; Personal or familial history of vitiligo or other pigmentation disorders ; Suspected Hypersensitivity to hydroquinone or trenaxemic acid ; Pregnancy or lactation ; History of ischemic heart disease or cerebrovascular disease ; History of coagulation disorders or deep vein thrombosis ; Usage of aspirin or Plavix.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of pigmentation. Timepoint: Before the intervention, 1 and 3 months after the intervention and three months after discontinuation intervention. Method of measurement: MASI Score , Digital photography , Patient satisfaction. | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal complications. Timepoint: Before the intervention, 1 and 3 months after the intervention and three months after discontinuation intervention. Method of measurement: Question of patients.;Reduce menstrual bleeding. Timepoint: Before the intervention, 1 and 3 months after the intervention and three months after discontinuation intervention. Method of measurement: Question of patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Afsane Ghayoumi
Tehran University of Medical Sciences
Outcome results
None listed