acute bactrial meningitis. Bacterial meningitis, unspecified
Conditions
Interventions
Intervention 1: that study group will receive NAC(1200mg BD) from begining of study until 10 days. Intervention 2: Control group:standard regimen for treatment of meningitis.
Prevention
that study group will receive NAC(1200mg BD) from begining of study until 10 days.
Control group:standard regimen for treatment of meningitis
Sponsors
Faculty of Pharmacy Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Filling consent form; Patients with diagnosis of acute bacterial meningitis who are candidated for receiving vancomycin; Age=16 yrs; Not receive vancomycin in last 2weeks Exclusion criteria: Clinical states which could change phahrmacokinetic of vancomycin (eg. burn, cystic fibrosis); Pregnancy; Patients with CKD who need dialysis ; Contraindication for vancomycin, treatment with other nephrotoxic agents.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of Cystatin-C. Timepoint: Baseline,5 and 10 days after treatment. Method of measurement: Turbidimetry.;Serum level of vancomycin. Timepoint: Baseline,5 and 10 days after treatment. Method of measurement: immunoassay technique,mcg/ml. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum level of creatinine. Timepoint: every other days from begining of study. Method of measurement: jaffe method?mg/dl. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Morteza Taheri
Faculty of pharmacy
Outcome results
None listed