colistin associated nephrotoxicity.
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive vitamin E in (alpha tocopherol) by dose of 400 IU/day in form of four 100 IU chewable tablets which will be chew by patients or will be crushe
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: candidate to receive colistin to treat infection with positive blood culture for multi-drug resistance gram negative organism which is sensitive to colistin pneumonia with positive tracheal culture for multi-drug resistance gram negative organism which is sensitive to colistin urinary tract infection with positive urinary culture for multi-drug resistance gram negative organism which is sensitive to colistin meningitis with positive Cerebrospinal fluid culture for multi-drug resistance gram negative organism which is sensitive to colistin receiving colistin for at least one week
Exclusion criteria
Exclusion criteria: Chronic kidney disease Acute kidney injury Receiving amphotericin B Receiving intravenous ascorbic acid Active bleeding Pregnancy Patient's death
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: blood sample.;Glomerular filtration rate. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: Cockcroft-Gault Formula.;Blood urea nitrogen. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: blood sample.;Urinary output. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: Measuring patient's urine volume. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Omid Moradi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed