Acute Kidney Injury. Acute kidney failure, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Colistin therapy begins with a dose of 9-12 million IU as 1-hr infusion and maintenance therapy continues after 12 hours of the loading dose, with a daily dose of 9
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with indication of colistin therapy patients with GFR> 60ml/min patients with magnesium blood level between 1.9 and 3 mg/dl
Exclusion criteria
Exclusion criteria: patients younger than 18 years patients with GFR< 60ml/min patients with magnesium blood level of less than 1.9 or more than 3 mg/dl Pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute Kidney Injury occurrence. Timepoint: Daily during the first week of colistin therapy. Method of measurement: The Kidney Disease Improving Global Outcomes (KDIGO) criteria for Acute Kidney Injury. | — |
Secondary
| Measure | Time frame |
|---|---|
| Escalation or de-escalation of therapy. Timepoint: Daily during the first week of colistin therapy. Method of measurement: Colistin daily dose observation.;Length of hospitalization. Timepoint: At the time of discharge. Method of measurement: Counting the number of days.;Death. Timepoint: Daily. Method of measurement: Records Observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Sahraei
Shahid Beheshti University of Medical Sciences
Outcome results
None listed