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The evaluation of the effects of Melia azedarach poultice in the treatment of head lice

Formulation of the product "azad derakht Latokh " based on traditional Iranian pharmacy, investigating a standardized method for its preparation, and clinical evaluation of its effects on ghommal (Pediculosis capitis) and Evaluation of the Insecticidal Effect of Its Extract on the Rice Weevil (Sitophilus oryzae)

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130911014630N12
Enrollment
50
Registered
2026-02-08
Start date
2026-04-21
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head lice. Pediculosis due to Pediculus humanus capitis

Interventions

Intervention 1: The intervention group receives a topical traditional formulation (liberated bark extract) twice daily for one week.alongside with permethrine shampoo. Intervention 2: Control group: r

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
5 Years to 50 Years

Inclusion criteria

Inclusion criteria: Definitive diagnosis of head lice: The presence of live lice or active eggs (nits) on the scalp hair must be confirmed by a physician or dermatologist. Absence of severe skin diseases: Participants must not have skin conditions such as eczema, psoriasis, or severe scalp infections. No use of anti-lice treatments: Participants must not have used any anti-lice treatment (chemical or herbal) within the past two weeks. Informed consent: Participants or their parents (in the case of children) must provide informed consent to participate in the study No known allergy to herbal compounds or 1% permethrin.

Exclusion criteria

Exclusion criteria: Age below 5 or above 50 years, or no confirmed head lice infestation by a physician. Presence of active/severe skin disease, known allergy to plant compounds, pregnancy or breastfeeding, uncontrolled systemic diseases, concurrent topical medication use, or lack of consent/compliance with the study.

Design outcomes

Primary

MeasureTime frame
The number of live lice present on the scalp. Timepoint: At the baseline, after first and second week. Method of measurement: Clinical observation.;Scalp Itching. Timepoint: At the baseline, after first and second week. Method of measurement: Visual analog scale (VAS).

Countries

Iran (Islamic Republic of)

Contacts

Public Contacthosein masoodi

Mazandaran University of Medical Sciences

hossein.masodi.1989@gmail.com+98 11 3354 2472

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026