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Comparison of two Cryotherapy techniques in gums color

Comparison of gingival depigmentation by open and closed cryosurgery in an Iranian population: A clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013091012487N3
Enrollment
32
Registered
2013-10-22
Start date
2011-02-04
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Pigmentation. Disorder of gingiva and edentulous alveolar ridge, unspecified

Interventions

Intervention 1: Case2: Cryoprob model C505T, Danesh Company, Iran. The prob was applied to pigmented areas (4 mm in diameter) for 10-15 second. This procedure was repeated 4 or 5 times for each segme
Treatment - Devices
Treatment - Drugs
Case2: Cryoprob model C505T, Danesh Company, Iran. The prob was applied to pigmented areas (4 mm in diameter) for 10-15 second. This procedure was repeated 4 or 5 times for each segment.
Case1: Liquid Nitrogen, Iran Liquid nitrogen100% ,Zeitun Company,Iran, was applied to pigmented areas by a cotton swab (4 mm in diameter) with a forward and backward rolling technique. This procedure

Sponsors

vice chancellor for research of Islamic Azad University Khorasgan Branch
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Gingival physiologic melanin pigmentation. Exclusion Criteria: Gingival pigmentation due to any systemic diseases, pigmentation caused by certain medications such as antimalarial drugs, anti-bacterial drug, smoking, gingivitis and known hypersensitivity to the liquid nitrogen and N2O.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Gingival color. Timepoint: Pretreatment, 2weeks,1, 3 and 6 months after the treatment. Method of measurement: using color analyzing systems of RGB and CMYK with photoshop software.

Secondary

MeasureTime frame
Recurrence of Pigmentation. Timepoint: 2week,1,3,6 months after the treatment. Method of measurement: color analyzing systems of RGB and CMYK with photoshop software.;Pain. Timepoint: During and post operation. Method of measurement: Visual Analogue Scale by Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmini, Shirin

Islamic Azad Dental School Khorasgan Branch, (Isfahan), Iran

Sh.amini@khuisf.ac.ir+98 31 1535 4053

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026