Radiation induced oral mucositis. Mucositis(oral) (oropharyngeal): NOS
Conditions
Interventions
Green tea mouth rinse with 3%concentration in the intervention group for the prevention of radiation induced mucositis and 0.9% saline were used as controls. These interventions will continue for 8
Prevention
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients older than 18 years old; patients that are diagnosed with the head and neck cancer; minimum dose of radiation therapy must be 50Gy to induce mucositis; patients who are able to use mouthwash before radiotherapy session; patients sign informed consent; at least 50% of the oral cavity area should be under radiation fields; having an ideal oral hygiene; absence of active infection in the oral cavity such as HSV, candida and aphthous ulcers. Exclusion criteria: patients currently suffering from any kind of oral diseases, e.g. active oral infection, ulcer, etc.; patients receiving chemotherapy combined with radiotherapy patients that are not able to use mouthwash; patients who have a broad extent of the lesions and grade IV mucositis; patients who use local anesthetic in the study; patients who are not willing to leave their unsafe habits such as smoking, alcohol, spicy and acidic foods; patients with a history of allergy to green tea; patients with lesions in the oral cavity area; patients who recently have used prostaglandin inhibitors, vitamin E and antioxidant supplements; lack of cooperation at every stage of project.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Pain and soreness. Timepoint: Every week. Method of measurement: Visual analogue scale.;Mucositis grading. Timepoint: Every week. Method of measurement: WHO grading(0-4). | — |
Primary
| Measure | Time frame |
|---|---|
| Type of mouthwash for treatment. Timepoint: after the termination of study. Method of measurement: revealing the mouth wash anyone was receiving after the end of study.;Sex. Timepoint: before the beginning of study. Method of measurement: observation.;Weight. Timepoint: At the beginning and end of radiotherapy. Method of measurement: Scaler.;Received radiation dose. Timepoint: The total dose received during the meetings. Method of measurement: Grey.;Age. Timepoint: at the beginning of study. Method of measurement: year.;Name of cancer. Timepoint: Before the beginning of study. Method of measurement: Pathology report.;Cancer location. Timepoint: Before the beginning of study. Method of measurement: Medical records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzeen Rashtiyani
Tehran University of Medical Sciences
Outcome results
None listed