The effect of curcumin supplementation on cardiovascular factors and kidney function on patients with chronic kidney disease

The effect of curcumin supplementation on cardiovascular risk factors and kidney function on patients with stage 3 and 4 of chronic kidney disease (CKD)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130903014551N4

Enrollment

Registered

2019-10-20

Start date

2019-07-22

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease. Other disorders resulting from impaired renal tubular function

Interventions

Intervention 1: Intervention group: : patients in this group will receive curcumin ,500 miligram in each day, for 10 weeks. Intervention 2: Control group: : patients in this group will receive One pl

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: The patient's tendency to participate in study and signing approval form no use of non steroidal anti-inflammatory drugs, Nicotinic Acid, estrogen, progesterone and Curcumin supplementation for at least one month before the start of the study Lack of drug addiction Lack of severe heart disease, liver failure and thyroid diseases, severe gastrointestinal bleeding and peptic ulcer disease, cholelithiasis, pregnancy or lactation Age between 18-75 years old Stage 3:GFR:15-29 Stage 4:GFR:30-59

Exclusion criteria

Exclusion criteria: kidney transplantation The use of herbal medicines as lipid lowering agents Receive omega-3 fatty acids and carnitine at least 1 month before the start of the study

Design outcomes

Primary

Measure	Time frame
Blood Urea Nitrogen. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Serum Creatinine. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Serum Albumin. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Urine Creatinine. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Urine Protein. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Parathyroid hormone. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Serum Potassium. Timepoint: before and after intervention. Method of measurement: Biochemistry.;High-density lipoprotein (HDL). Timepoint: before and after intervention. Method of measurement: blood sampling and direct measure.;Low-density lipoprotein (LDL). Timepoint: before and after intervention. Method of measurement: blood sampling and direct measure.;Triglycerid. Timepoint: before and after intervention. Method of measurement: blood sampling and direct measure.;Hemocysteine. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Blood pressure. Timepoint: before and after intervention. Method of measurement: hypertension high blood pressure according to the millimeters Mercury with the use of digital indicator.	—

Measure

Time frame

Blood Urea Nitrogen. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Serum Creatinine. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Serum Albumin. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Urine Creatinine. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Urine Protein. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Parathyroid hormone. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Serum Potassium. Timepoint: before and after intervention. Method of measurement: Biochemistry.;High-density lipoprotein (HDL). Timepoint: before and after intervention. Method of measurement: blood sampling and direct measure.;Low-density lipoprotein (LDL). Timepoint: before and after intervention. Method of measurement: blood sampling and direct measure.;Triglycerid. Timepoint: before and after intervention. Method of measurement: blood sampling and direct measure.;Hemocysteine. Timepoint: before and after intervention. Method of measurement: Biochemistry.;Blood pressure. Timepoint: before and after intervention. Method of measurement: hypertension high blood pressure according to the millimeters Mercury with the use of digital indicator.

—

Secondary

Measure	Time frame
Physical activity. Timepoint: At the beggining and end of intervention. Method of measurement: physical activity record questionnaire.;Dietary intake. Timepoint: At the beggining and end of intervention. Method of measurement: 3-day food record.;Body mass index (BMI). Timepoint: At the beggining and end of intervention. Method of measurement: Weight and height measurements by one person in the same center.	—

Measure

Time frame

Physical activity. Timepoint: At the beggining and end of intervention. Method of measurement: physical activity record questionnaire.;Dietary intake. Timepoint: At the beggining and end of intervention. Method of measurement: 3-day food record.;Body mass index (BMI). Timepoint: At the beggining and end of intervention. Method of measurement: Weight and height measurements by one person in the same center.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Morteza Safavi

Esfahan University of Medical Sciences

safavimorteza@yahoo.com????????-???.

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026