Condition 1: Dyslipidemia. Condition 2: Obesity.
Conditions
Interventions
Intervention 1: Curcuminoids are bioactive ingredients of turmeric. They belong to the polyphenol group of phytochemicals. The chemical name of curcumin is (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1
Treatment - Drugs
Placebo
Curcuminoids are bioactive ingredients of turmeric. They belong to the polyphenol group of phytochemicals. The chemical name of curcumin is (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,
Control group: placebo for 4 weeks
Sponsors
Mashhad University of Medical Sciences Research Council
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: obese subjects (with body mass index (BMI) = 30) who had either < 2 risk factors (except diabetes mellitus) for coronary heart disease (CHD) plus 160 mg/dL < LDL-C < 190 mg/dL, or = 2 CHD risk factors (except diabetes mellitus) and 130 mg/dL < LDL-C < 160 mg/dL. Exclusion criteria were history of systemic diseases (such as systemic lupus erythematosus, kidney disease, diabetes mellitus and established cardiovascular disease), consumption of drug supplements within the preceding 6 months and history of taking any lipid-lowering drug. Exclusion criteria: systemic disease or history of systemic disease (such as lupus, kidney disease, diabetes mellitus); history of cardiovascular disease; BMI < 30; consumption of drug supplements within the 6 months and history of taking any lipid lowering drug.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cholesterol. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Routine enzymatic methods using standard biochemistry kits on an autonalyzer.;Triglycerides. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Routine enzymatic methods using standard biochemistry kits on an autonalyzer.;HDL cholesterol. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Routine enzymatic methods using standard biochemistry kits on an autonalyzer.;LDL cholesterol. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Routine enzymatic methods using standard biochemistry kits on an autonalyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Vitamins. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzymatic assay.;Lipoprotein(a). Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzyme immunoassay.;Cathepsin D. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzyme immunoassay.;Vitamin C, vitamin E, lipoprotein(a) and cathepsin D. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Questionnaire, enzymatic and immunoassay kits.;Anxiety. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Questionnaire.;Serum small dense LDL. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzyme immunoassay.;Heat shock protein 27 antibodies. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzyme immunoassay.;Pro-oxidan-antioxidant blance. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Colorimetric assay.;Cytokines. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzyme immunoassay.;Superoxide dismutase. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzymatic assay.;Zinc. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzymatic assay.;Copper. Timepoint: Baseline, week 4, week 6 and week 10. Method of measurement: Enzymatic assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMajid Ghayour-Mobarhan
Cardiovascular Research Center, Mashhad University of Medical Sciences
Outcome results
None listed