Trauma. -
Conditions
Interventions
Intervention 1: Intervention group 1: Curcumin tablet twice daily (each tablet contain 500 mg Curcumin plus 5mg Piperine made by Sami-Sabinsa Group Limited) for 7 days. Intervention 2: Intervention gr
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
12 Years to No maximum
Inclusion criteria
Inclusion criteria: Minimum age of 12 years old ICU admission due to trauma Sign informed consent by the patients or his legal guardian Oral or enteral nutrition (nasogastric or orogastric tube)
Exclusion criteria
Exclusion criteria: Pregnancy or breast feeding Severe and active bleeding Re-hospitalization or refer from other hospitals or ICUs History of obstructive biliary disorders Allergy to Turmeric
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality during the intervention in the ICU (8-day ICU mortality). Timepoint: During the first 8-day ICU stay. Method of measurement: Observation and record in checklist.;60-days mortality. Timepoint: Mortality during the 60 days after entering to the study. Method of measurement: The information will be obtained by phone call.;30-days mortality. Timepoint: Mortality during the 30 days after entering to the study. Method of measurement: The information will be obtained by phone call. | — |
Secondary
| Measure | Time frame |
|---|---|
| 120-day mortality. Timepoint: Mortality during the 120 days after entering to the study. Method of measurement: The information will be obtained by phone call.;180-day mortality. Timepoint: Mortality during the 180 days after entering to the study. Method of measurement: The information will be obtained by phone call.;Duration of hospitalization. Timepoint: Duration of hospitalization will be recorded at the end of the study period. Method of measurement: Observation (record in checklist).;Duration of mechanical ventilation. Timepoint: Duration of mechanical ventilation will be recorded at the end of the intervention period. Method of measurement: Observation (record in checklist).;GCS (Glascow coma scale). Timepoint: Before and after the intervention period (7 days). Method of measurement: Summing the scores of eye opening, verbal response and motor response.;APACHE II(Acute Physiology and Chronic Health Evaluation). Timepoint: Before and after the intervention (7 days). Method of measurement: According to scoring system (APACHE is a severity-of-disease classification system that estimates mortality based on a number of laboratory values and patient signs taking both acute and chronic disease into account. This score will be calculated based on the guidelines and recorded in the checklist).;SOFA (Sequential Organ Failure Assessment). Timepoint: Before and after the intervention (7 days). Method of measurement: According to scoring system (SOFA score is a scoring system that assesses the performance of several organ systems in the body).;Modified nutrition risk in critically ill (mNUTRIC) score. Timepoint: Before and after the intervention (7 days). Method of measurement: According to scoring system (mNUTRIC is used to assess the nutrition risk in critically ill patients. This score estimates the risk according to some variables such as age, the number of comorbidities, hospitalization days, etc. This score will be calculated based on the guidelines and recorded in | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmihossein Sahebkar
Mashhad University of Medical Sciences
Outcome results
None listed