Comparison of the effect of metformin versus acarbose and metformin in treatment polycystic ovarian syndrome patients

Comparison of the effect of metformin versus acarbose and metformin in clinical presentation and endocrinology profiles in polycystic ovarian syndrome patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013082214438N1

Enrollment

Registered

2013-10-15

Start date

2013-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovarian syndrome. sclerocystic ovary syndrome

Interventions

Intervention 1: Tab metformin 500mg three times daily,orally and tab acarbose 100mg one time daily,orally for 4months. Intervention 2: Tab metformin 500mg three times daily,orally and tab placebo one

Treatment - Drugs

Tab metformin 500mg three times daily,orally and tab acarbose 100mg one time daily,orally for 4months

Tab metformin 500mg three times daily,orally and tab placebo one time daily/orally for 4months

Eligibility

Sex/Gender

Female

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age 20-45 years; women with pcos diagnosed by the rotterdam consensus criteria (presence 2 of the following 3 conditions: a)oligomenorrhea /amenorrhea b)clinical or biochemical evidence of hyperandrogenism c)polycystic ovaries on sonography) Exclusion criteria: patient with systemic disease such as cushing's syndrome; hyper or hypothyroidism; androgen secreting tumor; smokers; any systemic disease (liver ,renal,cardiovascular,diabet mellitus) ; receiving any drug for pcos such as aldacton,dian and clomiphen.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hirsutism. Timepoint: Before intervention - Four months after intervention. Method of measurement: Using Feriedman and Galway Scale.;Testostrone serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electr Komolomynsans method.;De Hydro Epi Andrestandion serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electr Komolomynsans method.;Fasting insulin serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Elysa asses.;Fasting sugar serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Enzyme.;Blood pressure. Timepoint: Before intervention - Four months after intervention. Method of measurement: Barometers.	—

Measure

Time frame

Hirsutism. Timepoint: Before intervention - Four months after intervention. Method of measurement: Using Feriedman and Galway Scale.;Testostrone serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electr Komolomynsans method.;De Hydro Epi Andrestandion serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electr Komolomynsans method.;Fasting insulin serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Elysa asses.;Fasting sugar serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Enzyme.;Blood pressure. Timepoint: Before intervention - Four months after intervention. Method of measurement: Barometers.

—

Secondary

Measure	Time frame
Triglycerid serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.;Cholestrol serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.;LDL serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.;HDL serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.	—

Measure

Time frame

Triglycerid serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.;Cholestrol serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.;LDL serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.;HDL serum level. Timepoint: Before intervention - Four months after intervention. Method of measurement: Serological test with Electro Komolynsans method.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Karimian, MD

kermanshah University Of Medical Science

maryam.karimian@kums.ac.ir+98 83 1427 6303

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026