Multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: In Intervention group, 20000 units IV Erythropoetin and 1000 mg methylprednisoloneIV has been prescribed for five consecutive days. Intervention 2: In control group, Normal saline sol
Treatment - Drugs
Placebo
In Intervention group, 20000 units IV Erythropoetin and 1000 mg methylprednisoloneIV has been prescribed for five consecutive days.
In control group, Normal saline solution (1000 mg, IV) and methylprednisolone 1000 mg IV has been prescribed for five consecutive days.
Sponsors
Tehran university of medical science research assistance
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: definite diagnosis of MS; age between 18 and 45 years old and motor force 3/5 or less at presentation. Exclusion criteria: pregnancy; brestfeeding; history of diabetes mellitus, hypertension, hyperlipidmia, heavy cigarette smoking, ischemic heart disease, myocardial infarction, cerebovasculaar accident; family history of ischemic heart disease and /or cerebrovascular accident before 45 years; presence of thrombocytosis; presence of polycytemia(hematocrite above 50% in males and above 45% in females); presence of CRF(chronic renal failure); history of any vasculitis or collagen vascular disease; use of contraceptive medication; use of iron substitution; past history of thromboembololic events and any kind of malignancy(treated or untreated).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EDSS. Timepoint: Before intervention, one, two three months after intervention. Method of measurement: Examination.;Ambulatory Index. Timepoint: Before intervention, one, two three months after intervention. Method of measurement: Examination.;MRI. Timepoint: Before intervention and three months after intervention. Method of measurement: Visual. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Pressure. Timepoint: Before intervention, five day and one and three months after intervention. Method of measurement: Sphygmomanometer.;RBC count. Timepoint: Before intervention, five day and three months after intervention. Method of measurement: Laboratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Fateme Najmi Varzaneh
Sina Hospital
Outcome results
None listed