Comparison of efficacy of laser Q-Switch 1,064 nm Nd: YAG with two different methods in the treatment of Malasma

Comparison of the efficacy and safety of Q-Switch 1,064 nm Nd:YAG Laser with and without carbon photo enhancer lotion on reducing skin pigmentation in patients with Melasma referred to Skin and Stem cell research center of Tehran University of Medical Sciences

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201308181159N9

Enrollment

Registered

2013-10-19

Start date

2013-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

melasma. Chloasma

Interventions

Intervention 1: Laser group with topical carbon: one half of face (A side) receives 3 sessions of Nd:YAG laser (fluence= 1.5-2 Joules per centimeter, spot size=7 Millimeters) with topical carbon at 1

Laser group with topical carbon: one half of face (A side) receives 3 sessions of Nd:YAG laser (fluence= 1.5-2 Joules per centimeter, spot size=7 Millimeters) with topical carbon at 1-week intervals

Laser group without topical carbon: In the other side (B group), the same laser therapy will be administered at one half of face receives 3 sessions of Nd:YAG laser (fluence=1.5-2 Joules per centimete

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 18 and 85 years old; Fitzpatrick skin type I-V; symmetric distribution of melasma the in both sides of patient's face; Exclusion criteria: -usage of pigment reducing topical treatments 2 weeks prior to the study -usage of peeling agents 2 weeks prior to the study -laser therapy for melasma 1 month prior to the study, and solarium usage one month prior to the treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Melanin Index. Timepoint: Before laser therapy. Method of measurement: Multi Probe adaptor.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Rahimi

Skin and Stem cell Research Center of Tehran University of Medical Sciences

elhamrahimimd@gmail.com+98 21 2223 9387

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026