Comparison the effect of vaginal isosorbide dinitrate in pre-induction cervical ripening in term pregnancy

Comparative study of the effect of vaginal isosorbide dinitrate in pre-induction cervical ripening in term pregnancy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N90

Enrollment

148

Registered

2018-05-02

Start date

2018-04-28

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy. Normal pregnancy

Interventions

Intervention 1: The first intervention group will receive 40 mg of vaginal isosorbide dinitrate within 24 hours. Intervention 2: The second intervention group will receive 20 mg of vaginal isosorbide

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Gestational age 37 weeks up to the end of the week Cephalic presentation No contraindications for isosorbide dinitrate Normal body volume index (BMI = 19.8-26), No history of previous cesarean section or any uterine scar

Exclusion criteria

Exclusion criteria: The presence of systemic diseases Estimate fetal weight more than 4 kg Vaginal bleeding Intolerance to ISDN, labor pain and oligohydramnios

Design outcomes

Primary

Measure	Time frame
Headache. Timepoint: At the beginning of the study, every 15 minutes to 1 hour, then every 30 minutes to 2 hours, and every 1 hour until delivery. Method of measurement: Ask the patient.;Nausea. Timepoint: At the beginning of the study, every 15 minutes to 1 hour, then every 30 minutes to 2 hours, and every 1 hour until delivery. Method of measurement: Ask the patient.;Blood pressure drop. Timepoint: At the beginning of the study, every 15 minutes to 1 hour, then every 30 minutes to 2 hours, and every 1 hour until delivery. Method of measurement: Sphygmomanometer.	—

Measure

Time frame

Headache. Timepoint: At the beginning of the study, every 15 minutes to 1 hour, then every 30 minutes to 2 hours, and every 1 hour until delivery. Method of measurement: Ask the patient.;Nausea. Timepoint: At the beginning of the study, every 15 minutes to 1 hour, then every 30 minutes to 2 hours, and every 1 hour until delivery. Method of measurement: Ask the patient.;Blood pressure drop. Timepoint: At the beginning of the study, every 15 minutes to 1 hour, then every 30 minutes to 2 hours, and every 1 hour until delivery. Method of measurement: Sphygmomanometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactfatemeh poyan

Kermanshah University of Medical Sciences

fatemehpoyan@yahoo.com+98 83 3427 4601

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026