Sepsis. Sepsis, unspecified
Conditions
Interventions
Intervention 1: The intervention group will receive 50 mg intravenous ascorbic every 6 hours and up to 6 grams and 200 mg thiamine every 12 hours for 4 days. Intervention 2: The control group will rec
Treatment - Drugs
Placebo
The intervention group will receive 50 mg intravenous ascorbic every 6 hours and up to 6 grams and 200 mg thiamine every 12 hours for 4 days.
The control group will receive 50 mg of placebo for 4 days.
Sponsors
Vice chancellor for research of Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Dysfunction of organs and SOFA score = 2 in patients whose antibiotic therapy is diagnosed. SOFA score = 2 in patients whose antibiotic therapy is diagnosed.
Exclusion criteria
Exclusion criteria: Pregnant women and people under the age of 18; ; Allergy to ascorbic acid, Chronic hemodialysis, Hemochromatotomy Sickness to G6PD Nephropathy oxalate or bilateral erlithiasis Receive simultaneously other antioxidants Patients with acquired immunodeficiency disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Organ dysfunction. Timepoint: The first day and fourth day study. Method of measurement: Based on laboratory and clinical criteria.;Length of stay in ICU. Timepoint: 28 days after intervention. Method of measurement: Based on patient records.;Mortality rate. Timepoint: 28 days after intervention. Method of measurement: Based on patient records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Bahrami
Kermanshah University of Medical Sciences
Outcome results
None listed