Tympanic Membrane Perforation. Perforation of tympanic membrane
Conditions
Interventions
In the intervention group, paper patches impregnated with exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) will be used in myringoplasty surgery to treat patients with ruptured ea
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Informed consent Patients diagnosed with a perforated tympanic membrane Age between 18-65 years Patients who have no contraindications to regenerative therapy or stem cell-derived therapies and no history of autoimmune diseases or immunodeficiency conditions that could interfere with the effects of exosome therapy.
Exclusion criteria
Exclusion criteria: Patients with chronic middle ear infections who do not respond to standard treatments Pregnant or breastfeeding women Patients who are currently enrolled in other clinical trials involving regenerative or stem cell therapies or have a history of allergic reactions to stem cell-derived products or any of the therapeutic ingredients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Repair of a ruptured eardrum. Timepoint: One, three and six months after treatment. Method of measurement: Using tympanometry and audiometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Taha Araghi
Kermanshah University of Medical Sciences
Outcome results
None listed