Investigating the effect of kefir probiotic on the inflammatory profile of saliva

Investigating the effect of kefir probiotic on salivary inflammatory profile in Bariatric surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N251

Enrollment

Registered

2025-06-08

Start date

2025-06-20

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity. Obesity due to excess calories

Interventions

Intervention 1: The intervention group will receive 100 cc of probiotic kefir daily for 8 weeks, in addition to their diet. Intervention 2: The control group will receive 100 cc of non-probiotic butte

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Informed consent Age between 20 and 60 years Performing bariatric surgery Body mass index greater than 40 or greater than 35 with underlying disease

Exclusion criteria

Exclusion criteria: History of chronic gastrointestinal disease, Acute phase of cancer or infectious and liver diseases History of corticosteroid and antibiotic use History of taking probiotic supplements and foods History of smoking; history of periodontitis

Design outcomes

Primary

Measure	Time frame
Salivary TNF-a levels. Timepoint: After the first post-surgery visit and after the end of the intervention. Method of measurement: Using an ELISA kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShabnam Azarnia

Islamic Azad University, Khorasgan branch

shabnamazarnia75@gmail.com+98 31 3535 4003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026