The effect of lidocaine and prilocaine for for inferior alveolar nerve block in mandibular impacted and partially impacted third molar surgery.

Comparison of hemodynamic changes following lidocaine 2% versus prilocaine 3% administration for inferior alveolar nerve block in mandibular impacted and partially impacted third molar surgery: A double blind clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N243

Enrollment

Registered

2025-03-10

Start date

2025-03-10

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted tooth. Impacted teeth

Interventions

Intervention 1: In the first intervention group, they will receive 2% lidocaine with epinephrine 1:100,000 from Darupakhsh Company, then two 1.8 ml carpools will be injected for inferior alveolar and

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Informed consent Age between 20 and 50 years Patients whose mandibular third molar is impacted or partially impacted

Exclusion criteria

Exclusion criteria: History of anticoagulant medications History of systemic disease, including cardiovascular disease, hypertension, diabetes, asthma, bronchospasm, or angioedema Nasal polyps Moderate to severe renal failure Liver failure Pregnant women

Design outcomes

Primary

Measure	Time frame
Systolic Blood Pressure. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a blood pressure monitor.;Diastolic blood pressure. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a blood pressure monitor.;Oxygen saturation percentage. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a blood pressure monitor.;Heart rate. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a pulse oximeter.	—

Measure

Time frame

Systolic Blood Pressure. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a blood pressure monitor.;Diastolic blood pressure. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a blood pressure monitor.;Oxygen saturation percentage. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a blood pressure monitor.;Heart rate. Timepoint: Before injection, immediately, and 15 minutes after injection. Method of measurement: Using a pulse oximeter.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Adibi

Islamic Azad University, Khorasgan Branch

m.adibi@gmail.com+98 31 3535 4003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026