Evaluation of the safety and efficacy of ophthalmic inserts in patients with open-angle glaucoma.

efficacy of dorzolamide-timolol fixed combination ocular inserts in patients with open-angle glaucoma: Phase I clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N242

Enrollment

Registered

2025-03-09

Start date

2025-03-15

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Open angle glaoucoma. Open-angle glaucoma

Interventions

Intervention 1: In the first intervention group, a dual slow-release system (containing the dual combination of timolol and dorzolamide) will be placed in their cul-de-sac. Intervention 2: The second

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Informed consent Patients with high eye pressure

Exclusion criteria

Exclusion criteria: All patients diagnosed with advanced glaucoma with a poor visual prognosis who have high IOP, have failed conventional triple-drug therapy, and are candidates for cyclodestructive surgery. Complex patients with diverse treatments

Design outcomes

Primary

Measure	Time frame
Intraocular pressure. Timepoint: Days zero and three. Method of measurement: Intraocular pressureUsing Goldmann Applanation Tonometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Leila Rezaei

Kermanshah University of Medical Sciences

Leyla_rezaei60@yahoo.com+98 83 3728 3602

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026