The effect of exosomes derived from umbilical cord stem cells on infertility in women with ovarian failure

Investigating the efficacy of exosomes derived from umbilical cord mesenchymal stem cells in treating infertility in women with chemotherapy or radiothrapy-induced ovarian failure

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N232

Enrollment

Registered

2024-11-19

Start date

2024-10-06

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature ovarian failure. Female infertility associated with anovulation

Interventions

The intervention group will receive one exosome unit equal to 200 µg of protein intraovarian. Exosomes are derived from umbilical cord mesenchymal stem cells. There is no control group..

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: informed consent Women with POI undergoing chemotherapy or radiothrapy FSH more than 10 mIU/mL Normal infectious tests (VDRL, HCV, HBS Ag, HIV)

Exclusion criteria

Exclusion criteria: History of any type of immunotherapy in the medical record Thin endometrium Organic diseases of the endometrium Hydrosalpinx endometriosis stage 3 or 4 Asherman syndrome Chromosomal disorders of couples Immune system diseases including rheumatoid arthritis and thyroid autoimmunity during the last three months

Design outcomes

Primary

Measure	Time frame
Fever and chills. Timepoint: End of study. Method of measurement: Ask the patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. kamran Mansouri

Kermanshah University of Medical Sciences

kamranmansouri@gmail.com+98 83 3427 4618

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026